Molecular basis of cancer?

Published on Aug 20th, 2010 under All.By admin

[Epithelial Cancer related Question]

In my pathology book it was said that: “Many cancer cells acquire growth self-sufficiency bu acquiring the ability to synthesize the same growth factors to which they are responsive”…. few lines later i found that “Hepatocyte growth factor (HGF) and its receptor c-Met are both over-expressed in follicular carcinoma of the thyroid. Now, are thyroid epithelial cells normally resposive to HGF? Isn’t HGF a stimulator for growth of hepatocytes only?

Thanks for your help!

Responses below:

Tags: basis, Cancer, Cancer Cells, Carcinoma, Carcinoma Of The Thyroid, Epithelial Cancer, Epithelial Cells, Follicular Carcinoma, Growth Factors, Hgf, Molecular, Molecular Basis Of Cancer, Pathology, Self Sufficiency, Thanks For Your Help, Thanks For Your Help, Thyroid

3 Comments

R. Gaspari on August 20th, 2010

I’m not an oncologist and I beg your apology since I don’t have familiarity with HGF and the molecular basis for whichever entity your referring to.

If Robbins doesn’t provide an adequate explanation for it, perhaps you may find a more helpful explanation in Abeloff.

Tuncay U on August 20th, 2010

many cancer cells are in turgol(ballon with water).

jdansng on August 20th, 2010

In endocrinology, many growth factors are named due to the place where they are first discovered. It is only later they are found to have more functions. This is the case of Hepatocyte Growth Factor. So yes, thyroid epithelial cells are responsive to HGF alongside of many other cells.

Epithelial Cancer

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